Brain tumours can affect people of any age, including children, although they tend to be more common in older adults. More than 9,000 people are diagnosed with primary brain tumours in the UK each year.
Fighting to Cure Brain Tumours: It's in our DNA
A paradigm shift for Neuro-Oncology
Brain tumours present a wide and diverse landscape of genetic and morphological aberrations. We believe “one size does not fit all” and personalised treatment may overcome the limitations and pave the road to favourable outcomes.
This flagship programme provides the necessary framework so that we may search the vast disease map, locate the targets for intervention, and re-shape the future of therapy.
We will leverage the existing clusters of excellence in biomedical engineering and clinical neurosciences to outline the complexity of the disease on neuro and radiogenomics basis and to offer novel and efficient therapies.
Dr Sotirios Bisdas
“Frankly speaking, this flagship program sets the foundation and roadmap for the development of cutting edge, precise and personalised diagnosis and treatment of brain tumours.”
Senior Lecturer, UCL Institute of Neurology
Consultant in Neuroradiology, The National Hospital for Neurology and Neurosurgery
Metabolic and Microstructural Imaging for Diagnosis and Surveillance
The image above shows a metabolic map of brain tumour showing the aggressive regions (red) which are decisive for the patient’s survival.
By using the latest imaging techniques in our treatment and diagnosis we are able to pinpoint brain tumours and offer bespoke treatment plans depending on the type, size and location.
Semi-Automated Tissue Segmentation Software for Brain Tumours
3D rendering of a semi-automated tissue segmentation of the healthy grey and white matter (purple and red respectively), and the tumour (transparent blue) with it’s necrotic (green) and vascularised (yellow) regions.
The images without purple put together the WM/GM into one single region (healthy brain tissues) in red.
Using Radiogenomics to Understand Brain Tumours
Using techniques that combine neuro-imaging and genetics data, we aim to understand the connection genetic changes in the cancer tissue and the resulting metabolic and physiologic properties of the brain tumour.
Later on, this knowledge will allow us, based on imaging data alone, estimate the genetic markup of the tumour and inform treatment selection and treatment outcome prediction.